Ontology highlight
ABSTRACT:
SUBMITTER: Byun S
PROVIDER: S-EPMC10841513 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20231106 49
An enantioselective carbene-catalyzed radical-radical coupling of acyl imidazoles and racemic Hantzsch esters is disclosed. This method involves the coupling of an N-heterocyclic carbene-derived ketyl radical and a secondary sp<sup>3</sup> -carbon radical and allows access to chiral α-aryl aliphatic ketones in moderate-to-good yields and enantioselectivities without any competitive epimerization. The utility of this protocol is highlighted by the late-stage functionalization of various pharmaceu ...[more]