Ontology highlight
ABSTRACT:
SUBMITTER: Lee A
PROVIDER: S-EPMC6527340 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190327 18
A direct decarboxylative strategy for the generation of aza-o-quinone methides (aza-o-QMs) by N-heterocyclic carbene (NHC) catalysis has been discovered and explored. This process requires no stoichiometric additives in contrast with current approaches. Aza-o-QMs react with trifluoromethyl ketones through a formal [4+2] manifold to access highly enantioenriched dihydrobenzoxazin-4-one products, which can be converted to dihydroquinolones through an interesting stereoretentive aza-Petasis-Ferrier ...[more]