Ontology highlight
ABSTRACT:
SUBMITTER: He R
PROVIDER: S-EPMC10864178 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
He Ruiqiao R Zhu Junjie J Ji Peifeng P Zhao Fangqing F
Nature methods 20231204 2
Small extracellular vesicles (sEVs) are emerging as pivotal players in a wide range of physiological and pathological processes. However, a pressing challenge has been the lack of high-throughput techniques capable of unraveling the intricate heterogeneity of sEVs and decoding the underlying cellular behaviors governing sEV secretion. Here we leverage droplet-based single-cell RNA sequencing (scRNA-seq) and introduce an algorithm, SEVtras, to identify sEV-containing droplets and estimate the sEV ...[more]