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Identification of a progenitor of the CTX-M-9 group of extended-spectrum beta-lactamases from Kluyvera georgiana isolated in Guyana.

ABSTRACT: Chromosomal beta-lactamase genes (bla(KLUY)) from six Kluyvera georgiana strains isolated in Guyana were cloned and expressed in Escherichia coli. KLUY-1 exhibited 100% amino acid identity with the extended-spectrum beta-lactamase CTX-M-14. We also show that a 2.7-kb Kluyvera chromosomal region exhibits 99% nucleotide identity to a portion of In60 that includes bla(CTX-M-9).

SUBMITTER: Olson AB

PROVIDER: S-EPMC1087624 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature

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Identification of a progenitor of the CTX-M-9 group of extended-spectrum beta-lactamases from Kluyvera georgiana isolated in Guyana.

Olson Adam B AB Silverman M M Boyd David A DA McGeer Allison A Willey Barbara M BM Pong-Porter V V Daneman N N Mulvey Michael R MR

Antimicrobial agents and chemotherapy 20050501 5

Chromosomal beta-lactamase genes (bla(KLUY)) from six Kluyvera georgiana strains isolated in Guyana were cloned and expressed in Escherichia coli. KLUY-1 exhibited 100% amino acid identity with the extended-spectrum beta-lactamase CTX-M-14. We also show that a 2.7-kb Kluyvera chromosomal region exhibits 99% nucleotide identity to a portion of In60 that includes bla(CTX-M-9). ...[more]

PMID: 15855541

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Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria.

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