Ontology highlight
ABSTRACT:
SUBMITTER: Filippini L
PROVIDER: S-EPMC10953394 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Filippini Ludovica L Ortner Nadine J NJ Kaserer Teresa T Striessnig Jörg J
British journal of pharmacology 20230314 10
Voltage-gated L-type Ca<sup>2+</sup> -channels (LTCCs) are the target of Ca<sup>2+</sup> -channel blockers (CCBs), which are in clinical use for the evidence-based treatment of hypertension and angina. Their cardiovascular effects are largely mediated by the Ca<sub>v</sub> 1.2-subtype. However, based on our current understanding of their physiological and pathophysiological roles, Ca<sub>v</sub> 1.3 LTCCs also appear as attractive drug targets for the therapy of various diseases, including treat ...[more]