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Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes.

ABSTRACT: Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca2+ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca2+ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca2+ rise in pre-myelinating OLs, which is primarily mediated by Ca2+ -permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K+ caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca2+ influx via P/Q- and L-type voltage-gated Ca2+ (Cav ) channels. Thus, glutamate is a key signaling factor in dynamic communication between neurons and OLs that triggers Ca2+ transients via AMPARs and Cav channels in developing OLs. The results provide a mechanism for OL Ca2+ dynamics in response to neuronal input, which has implications for OL development and myelination.

SUBMITTER: Barron T

PROVIDER: S-EPMC6771819 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes.

Barron Tara T Kim Jun Hee JH

Glia 20190717 10

Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca2+ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca2+ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca2+ rise in pre-myelinating OLs, which is primarily mediated by Ca2+ -permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and ...[more]

PMID: 31313856

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Dataset Information

Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes.

Publications

Neuronal input triggers Ca<sup>2+</sup> influx through AMPA receptors and voltage-gated Ca<sup>2+</sup> channels in oligodendrocytes.

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