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Incremental value of left ventricular shape parameters measured by gated SPECT MPI in predicting the super-response to CRT.


ABSTRACT:

Background

The purpose of this study was to evaluate the predictive value of left ventricular (LV) shape parameters measured by gated SPECT myocardial perfusion imaging (MPI) in super-responders enrolled in the VISION-CRT trial.

Methods

One hundred and ninety-nine patients who met standard criteria for CRT from multiple centers were enrolled in this study. End-systolic eccentricity (ESE) and end-diastolic eccentricity (EDE) were measures of LV shape. Super-responders were the patients who had a relative increase in left ventricular ejection fraction (LVEF) ≥ 15%.

Results

Complete data were obtained in 165 patients, and 43.6% of them were classified as super-responders. ESE was an independent predictor of CRT super-responders in univariate (OR 12.59, 95% CI 1.56-101.35, P = .017) and multivariate analysis (OR 35.71, 95% CI 1.66-766.03, P = .006). ESE had an incremental value over significant clinical and SPECT imaging variables, including angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker, coronary artery disease, myocardial infarction, LVEF, end-diastolic volume index, and scar burden (AUC 0.82 vs. 0.80, sensitivity 0.68 vs. 0.65, specificity 0.82 vs. 0.78).

Conclusions

LV shape parameters derived from gated SPECT MPI have the promise to improve the prediction of the super-response to CRT. Moreover, ESE provides incremental value over existing clinical and nuclear imaging variables.

SUBMITTER: He Z 

PROVIDER: S-EPMC10959067 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Incremental value of left ventricular shape parameters measured by gated SPECT MPI in predicting the super-response to CRT.

He Zhuo Z   de Amorim Fernandes Fernando F   do Nascimento Erivelton Alessandro EA   Garcia Ernest V EV   Mesquita Claudio T CT   Zhou Weihua W  

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20210127 4


<h4>Background</h4>The purpose of this study was to evaluate the predictive value of left ventricular (LV) shape parameters measured by gated SPECT myocardial perfusion imaging (MPI) in super-responders enrolled in the VISION-CRT trial.<h4>Methods</h4>One hundred and ninety-nine patients who met standard criteria for CRT from multiple centers were enrolled in this study. End-systolic eccentricity (ESE) and end-diastolic eccentricity (EDE) were measures of LV shape. Super-responders were the pati  ...[more]

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