Dataset Information

Effect of data conserving respiratory motion compensation on left ventricular functional parameters assessed in gated myocardial perfusion SPECT.

ABSTRACT:

Background

Respiratory motion compromises image quality in myocardial perfusion (MP) single-photon emission computed tomography (SPECT) imaging and may affect analysis of left ventricular (LV) functional parameters, including phase analysis-quantified mechanical dyssynchrony parameters. In this paper, we investigate the performance of two algorithms, respiratory blur modeling (RBM) and joint motion-compensated (JMC) ordered-subsets expectation maximization (OSEM), and the effects of motion compensation on cardiac-gated MP-SPECT studies.

Methods

Image acquisitions were carried out with a dual-detector SPECT/CT system in list-mode format. A cardiac phantom was imaged as stationary and under respiratory motion. The images were reconstructed with OSEM, RBM-OSEM, and JMC-OSEM algorithms, and compared in terms of mean squared error (MSE). Subsequently, MP-SPECT data of 19 patients were binned into dual-gated (respiratory and cardiac gating) projection images. The images of the patients were analyzed with Quantitative Gated SPECT (QGS) 2012 program (Cedars-Sinai Medical Center, USA). The parameters of interest were LV volumes, ejection fraction, wall motion, wall thickening, phase analysis, and perfusion parameters.

Results

In phantom experiment, compared to the stationary OSEM reconstruction, the MSE values for OSEM, RBM-OSEM, and JMC-OSEM were 8.5406·10^-5,2.7190·10^-5, and 2.0795·10^-5, respectively. In the analysis of LV function, use of JMC had a small but statistically significant (p < 0.05) effect on several parameters: it increased LV volumes and standard deviation of phase angle histogram, and it decreased ejection fraction, global wall motion, and lateral, septal, and apical perfusion.

Conclusions

Compared to standard OSEM algorithm, RBM-OSEM and JMC-OSEM both improve image quality under motion. Motion compensation has a minor effect on LV functional parameters.

SUBMITTER: Kortelainen MJ

PROVIDER: S-EPMC7818343 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Effect of data conserving respiratory motion compensation on left ventricular functional parameters assessed in gated myocardial perfusion SPECT.

Kortelainen Matti J MJ Koivumäki Tuomas M TM Vauhkonen Marko J MJ Hakulinen Mikko A MA

EJNMMI physics 20210121 1

<h4>Background</h4>Respiratory motion compromises image quality in myocardial perfusion (MP) single-photon emission computed tomography (SPECT) imaging and may affect analysis of left ventricular (LV) functional parameters, including phase analysis-quantified mechanical dyssynchrony parameters. In this paper, we investigate the performance of two algorithms, respiratory blur modeling (RBM) and joint motion-compensated (JMC) ordered-subsets expectation maximization (OSEM), and the effects of moti ...[more]

PMID: 33475904

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Project description:BackgroundIn clinical practice and in clinical trials, echocardiography and scintigraphy are used the most for the evaluation of global left ejection fraction (LVEF) and left ventricular (LV) volumes. Actually, poor quality imaging and geometrical assumptions are the main limitations of LVEF measured by echocardiography. Contrast agents and 3D echocardiography are new methods that may alleviate these potential limitations.MethodsTherefore we sought to examine the accuracy of contrast 3D echocardiography for the evaluation of LV volumes and LVEF relative to MIBI gated SPECT as an independent reference. In 43 patients addressed for chest pain, contrast 3D echocardiography (RT3DE) and MIBI gated SPECT were prospectively performed on the same day. The accuracy and the variability of LV volumes and LVEF measurements were evaluated.ResultsDue to good endocardial delineation, LV volumes and LVEF measurements by contrast RT3DE were feasible in 99% of the patients. The mean LV end-diastolic volume (LVEDV) of the group by scintigraphy was 143 +/- 65 mL and was underestimated by triplane contrast RT3DE (128 +/- 60 mL; p < 0.001) and less by full-volume contrast RT3DE (132 +/- 62 mL; p < 0.001). Limits of agreement with scintigraphy were similar for triplane andfull-volume, modalities with the best results for full-volume. Results were similar for calculation of LV end-systolic volume (LVESV). The mean LVEF was 44 +/- 16% with scintigraphy and was not significantly different with both triplane contrast RT3DE (45 +/- 15%) and full-volume contrast RT3DE (45 +/- 15%). There was an excellent correlation between two different observers for LVEDV, LVESV and LVEF measurements and inter observer agreement was also good for both contrast RT3DE techniques.ConclusionContrast RT3DE allows an accurate assessment of LVEF compared to the LVEF measured by SPECT, and shows low variability between observers. Although RT3DE triplane provides accurate evaluation of left ventricular function, RT3DE full-volume is superior to triplane modality in patients with suspected coronary artery disease.

Dataset Information

Effect of data conserving respiratory motion compensation on left ventricular functional parameters assessed in gated myocardial perfusion SPECT.

Background

Methods

Results

Conclusions

Publications

Effect of data conserving respiratory motion compensation on left ventricular functional parameters assessed in gated myocardial perfusion SPECT.

Similar Datasets

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