Ontology highlight
ABSTRACT:
SUBMITTER: Chung KJ
PROVIDER: S-EPMC11302722 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Chung Kevin J KJ Abdelhafez Yasser G YG Spencer Benjamin A BA Jones Terry T Tran Quyen Q Nardo Lorenzo L Chen Moon S MS Sarkar Souvik S Medici Valentina V Lyo Victoria V Badawi Ramsey D RD Cherry Simon R SR Wang Guobao G
medRxiv : the preprint server for health sciences 20240727
Blood-brain barrier (BBB) disruption is involved in the pathogenesis and progression of many neurological and systemic diseases. Non-invasive assessment of BBB permeability in humans has mainly been performed with dynamic contrast-enhanced magnetic resonance imaging, evaluating the BBB as a structural barrier. Here, we developed a novel non-invasive positron emission tomography (PET) method in humans to measure the BBB permeability of molecular radiotracers that cross the BBB through different t ...[more]