Blood-brain barrier permeability analysis of plant ceramides.
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ABSTRACT:
SUBMITTER: Eguchi K
PROVIDER: S-EPMC7605672 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Blood-brain barrier permeability analysis of plant ceramides.
Eguchi Koichi K Mikami Daisuke D Sun Hui H Tsumita Takuya T Takahashi Kaori K Mukai Katsuyuki K Yuyama Kohei K Igarashi Yasuyuki Y
PloS one 20201102 11
Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate a variety of cell functions. In plants, ceramides are mostly present in a glucosylated glucosylceramide (GlcCer) form. We previously showed that oral administration of konjac-derived GlcCer to a mouse model of Alzheimer's disease reduced brain amyloid-β and amyloid plaques. Dietary plant GlcCer compounds are absorbed as ceramides, but it is unclear whether they can cross the blood-brain barrier (BBB ...[more]
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