Ontology highlight
ABSTRACT:
SUBMITTER: Abu Fanne R
PROVIDER: S-EPMC4423729 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Neuropharmacology 20100106 7
Tissue type plasminogen activator (tPA) can induce neuronal apoptosis, disrupt the blood-brain barrier (BBB), and promote dilation of the cerebral vasculature. The timing, sequence and contributions of these and other deleterious effects of tPA and their contribution to post-ischemic brain damage after stroke, have not been fully elucidated. To dissociate the effects of tPA on BBB permeability, cerebral vasodilation and protease-dependent pathways, we developed several tPA mutants and PAI-1 deri ...[more]