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Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.


ABSTRACT: Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e-118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6'-sialyllactose (P = 2.2e-9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P < 0.01). Thus, we report novel genetic factors associated with HMOs, some of which may protect the respiratory health of children.

SUBMITTER: Ambalavanan A 

PROVIDER: S-EPMC11375010 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.

Ambalavanan Amirthagowri A   Chang Le L   Choi Jihoon J   Zhang Yang Y   Stickley Sara A SA   Fang Zhi Y ZY   Miliku Kozeta K   Robertson Bianca B   Yonemitsu Chloe C   Turvey Stuart E SE   Mandhane Piushkumar J PJ   Simons Elinor E   Moraes Theo J TJ   Anand Sonia S SS   Paré Guillaume G   Williams Janet E JE   Murdoch Brenda M BM   Otoo Gloria E GE   Mbugua Samwel S   Kamau-Mbuthia Elizabeth W EW   Kamundia Egidioh W EW   Gindola Debela K DK   Rodriguez Juan M JM   Pareja Rossina G RG   Sellen Daniel W DW   Moore Sophie E SE   Prentice Andrew M AM   Foster James A JA   Kvist Linda J LJ   Neibergs Holly L HL   McGuire Mark A MA   McGuire Michelle K MK   Meehan Courtney L CL   Sears Malcolm R MR   Subbarao Padmaja P   Azad Meghan B MB   Bode Lars L   Duan Qingling Q  

Nature communications 20240904 1


Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p  ...[more]

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