Ontology highlight
ABSTRACT:
SUBMITTER: Suspene R
PROVIDER: S-EPMC1149401 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Suspène Rodolphe R Guétard Denise D Henry Michel M Sommer Peter P Wain-Hobson Simon S Vartanian Jean-Pierre JP
Proceedings of the National Academy of Sciences of the United States of America 20050526 23
Because the replication of hepatitis B virus (HBV) proceeds via an obligatory reverse transcription step in the viral capsid, cDNA is potentially vulnerable to editing by cytidine deaminases of the APOBEC3 family. To date only two edited HBV genomes, referred to as G --> A hypermutants, have been described in vivo. Recent work suggested that HBV replication was indeed restricted by APOBEC3G but by a mechanism other than editing. The issue of restriction has been explored by using a sensitive PCR ...[more]