Ontology highlight
ABSTRACT:
SUBMITTER: Silvas TV
PROVIDER: S-EPMC6699113 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Silvas Tania V TV Schiffer Celia A CA
Protein science : a publication of the Protein Society 20190710 9
Nucleic acid editing enzymes are essential components of the human immune system that lethally mutate viral pathogens and somatically mutate immunoglobulins. Among these enzymes are cytidine deaminases of the apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) super family, each with unique target sequence specificity and subcellular localization. We focus on the DNA-editing APOBEC3 enzymes that have recently attracted attention because of their involvement in cancer and po ...[more]