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AS2TS system for protein structure modeling and analysis.

ABSTRACT: We present a set of programs and a website designed to facilitate protein structure comparison and protein structure modeling efforts. Our protein structure analysis and comparison services use the LGA (local-global alignment) program to search for regions of local similarity and to evaluate the level of structural similarity between compared protein structures. To facilitate the homology-based protein structure modeling process, our AL2TS service translates given sequence-structure alignment data into the standard Protein Data Bank (PDB) atom records (coordinates). For a given sequence of amino acids, the AS2TS (amino acid sequence to tertiary structure) system calculates (e.g. using PSI-BLAST PDB analysis) a list of the closest proteins from the PDB, and then a set of draft 3D models is automatically created. Web services are available at http://as2ts.llnl.gov/.

SUBMITTER: Zemla A

PROVIDER: S-EPMC1160218 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature

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AS2TS system for protein structure modeling and analysis.

Zemla A A Zhou C Ecale CE Slezak T T Kuczmarski T T Rama D D Torres C C Sawicka D D Barsky D D

Nucleic acids research 20050701 Web Server issue

We present a set of programs and a website designed to facilitate protein structure comparison and protein structure modeling efforts. Our protein structure analysis and comparison services use the LGA (local-global alignment) program to search for regions of local similarity and to evaluate the level of structural similarity between compared protein structures. To facilitate the homology-based protein structure modeling process, our AL2TS service translates given sequence-structure alignment da ...[more]

PMID: 15980437

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