Ontology highlight
ABSTRACT:
SUBMITTER: Louis SF
PROVIDER: S-EPMC1172233 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Louis Sherif F SF Vermolen Bart J BJ Garini Yuval Y Young Ian T IT Guffei Amanda A Lichtensztejn Zelda Z Kuttler Fabien F Chuang Tony C Y TC Moshir Sharareh S Mougey Virginie V Chuang Alice Y C AY Kerr Paul Donald PD Fest Thierry T Boukamp Petra P Mai Sabine S
Proceedings of the National Academy of Sciences of the United States of America 20050627 27
In previous work, we showed that telomeres of normal cells are organized within the 3D space of the interphase nucleus in a nonoverlapping and cell cycle-dependent manner. This order is distorted in tumor cell nuclei where telomeres are found in close association forming aggregates of various numbers and sizes. Here we show that c-Myc overexpression induces telomeric aggregations in the interphase nucleus. Directly proportional to the duration of c-Myc deregulation, we observe three or five cycl ...[more]