Ontology highlight
ABSTRACT:
SUBMITTER: Nozawa RS
PROVIDER: S-EPMC5473940 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nozawa Ryu-Suke RS Boteva Lora L Soares Dinesh C DC Naughton Catherine C Dun Alison R AR Buckle Adam A Ramsahoye Bernard B Bruton Peter C PC Saleeb Rebecca S RS Arnedo Maria M Hill Bill B Duncan Rory R RR Maciver Sutherland K SK Gilbert Nick N
Cell 20170601 7
Higher eukaryotic chromosomes are organized into topologically constrained functional domains; however, the molecular mechanisms required to sustain these complex interphase chromatin structures are unknown. A stable matrix underpinning nuclear organization was hypothesized, but the idea was abandoned as more dynamic models of chromatin behavior became prevalent. Here, we report that scaffold attachment factor A (SAF-A), originally identified as a structural nuclear protein, interacts with chrom ...[more]