Ontology highlight
ABSTRACT:
SUBMITTER: Lewis CM
PROVIDER: S-EPMC1180588 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Lewis Cathryn M CM Levinson Douglas F DF Wise Lesley H LH DeLisi Lynn E LE Straub Richard E RE Hovatta Iiris I Williams Nigel M NM Schwab Sibylle G SG Pulver Ann E AE Faraone Stephen V SV Brzustowicz Linda M LM Kaufmann Charles A CA Garver David L DL Gurling Hugh M D HM Lindholm Eva E Coon Hilary H Moises Hans W HW Byerley William W Shaw Sarah H SH Mesen Andrea A Sherrington Robin R O'Neill F Anthony FA Walsh Dermot D Kendler Kenneth S KS Ekelund Jesper J Paunio Tiina T Lönnqvist Jouko J Peltonen Leena L O'Donovan Michael C MC Owen Michael J MJ Wildenauer Dieter B DB Maier Wolfgang W Nestadt Gerald G Blouin Jean-Louis JL Antonarakis Stylianos E SE Mowry Bryan J BJ Silverman Jeremy M JM Crowe Raymond R RR Cloninger C Robert CR Tsuang Ming T MT Malaspina Dolores D Harkavy-Friedman Jill M JM Svrakic Dragan M DM Bassett Anne S AS Holcomb Jennifer J Kalsi Gursharan G McQuillin Andrew A Brynjolfson Jon J Sigmundsson Thordur T Petursson Hannes H Jazin Elena E Zoëga Tomas T Helgason Tomas T
American journal of human genetics 20030611 1
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studie ...[more]