Ontology highlight
ABSTRACT:
SUBMITTER: Saffin JM
PROVIDER: S-EPMC1183541 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Saffin Jean-Michel JM Venoux Magali M Prigent Claude C Espeut Julien J Poulat Francis F Giorgi Dominique D Abrieu Ariane A Rouquier Sylvie S
Proceedings of the National Academy of Sciences of the United States of America 20050727 32
We have identified a unique human microtubule-associated protein (MAP) named ASAP for ASter-Associated Protein. ASAP localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis and directly binds to purified microtubules by its COOH-terminal domain. Overexpression of ASAP induces profound bundling of cytoplasmic microtubules in interphase cells and aberrant monopolar spindles in mitosis. Depletion of ASAP by RNA in ...[more]