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Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.


ABSTRACT: B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family members BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. BAX and BAK are critical mediators of B cell death induced by multiple stimuli. In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but not to CpG-DNA. Furthermore, inducible deletion of Bax and Bak in adult mice results in the development of severe autoimmune disease.

SUBMITTER: Takeuchi O 

PROVIDER: S-EPMC1183578 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature

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Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.

Takeuchi Osamu O   Fisher Jill J   Suh Heikyung H   Harada Hisashi H   Malynn Barbara A BA   Korsmeyer Stanley J SJ  

Proceedings of the National Academy of Sciences of the United States of America 20050729 32


B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family members BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. BAX and BAK are critical mediators of B cell death induced by multiple stimuli. In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but  ...[more]

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