Ontology highlight
ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC4599777 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zhang Tejia T Walensky Loren D LD Saghatelian Alan A
ACS chemical biology 20150406 6
BCL-2 proteins are key regulators of programmed cell death. The interplay between pro and antiapoptotic BCL-2 members has important roles in many cancers. In addition to their apoptotic function, recent evidence supports key nonapoptotic roles for several BCL-2 proteins. We used an unbiased lipidomics strategy to reveal that the proapoptotic proteins BAX, and to a lesser extent BAK, regulate the cellular inflammatory response by mediating COX-2 expression and prostaglandin biosynthesis. COX-2 up ...[more]