Ontology highlight
ABSTRACT:
SUBMITTER: Miller JP
PROVIDER: S-EPMC1189342 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Miller John P JP Miller John P JP Lo Russell S RS Ben-Hur Asa A Desmarais Cynthia C Stagljar Igor I Noble William Stafford WS Fields Stanley S
Proceedings of the National Academy of Sciences of the United States of America 20050810 34
We carried out a large-scale screen to identify interactions between integral membrane proteins of Saccharomyces cerevisiae by using a modified split-ubiquitin technique. Among 705 proteins annotated as integral membrane, we identified 1,985 putative interactions involving 536 proteins. To ascribe confidence levels to the interactions, we used a support vector machine algorithm to classify interactions based on the assay results and protein data derived from the literature. Previously identified ...[more]