Ontology highlight
ABSTRACT:
SUBMITTER: Cokol M
PROVIDER: S-EPMC4281482 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cokol Murat M Weinstein Zohar B ZB Yilancioglu Kaan K Tasan Murat M Doak Allison A Cansever Dilay D Mutlu Beste B Li Siyang S Rodriguez-Esteban Raul R Akhmedov Murodzhon M Guvenek Aysegul A Cokol Melike M Cetiner Selim S Giaever Guri G Iossifov Ivan I Nislow Corey C Shoichet Brian B Roth Frederick P FP
Chemistry & biology 20140403 4
One drug may suppress the effects of another. Although knowledge of drug suppression is vital to avoid efficacy-reducing drug interactions or discover countermeasures for chemical toxins, drug-drug suppression relationships have not been systematically mapped. Here, we analyze the growth response of Saccharomyces cerevisiae to anti-fungal compound ("drug") pairs. Among 440 ordered drug pairs, we identified 94 suppressive drug interactions. Using only pairs not selected on the basis of their supp ...[more]