Ontology highlight
ABSTRACT:
SUBMITTER: Schaar BT
PROVIDER: S-EPMC1199551 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Schaar Bruce T BT McConnell Susan K SK
Proceedings of the National Academy of Sciences of the United States of America 20050907 38
Discoveries from human and mouse genetics have identified cytoskeletal and signaling proteins that are essential for neuronal migration in the developing brain. To provide a meaningful context for these studies, we took an unbiased approach of correlative electron microscopy of neurons migrating through a three-dimensional matrix, and characterized the cytoskeletal events that occur as migrating neurons initiate saltatory forward movements of the cell nucleus. The formation of a cytoplasmic dila ...[more]