Ontology highlight
ABSTRACT:
SUBMITTER: Cappello S
PROVIDER: S-EPMC3164498 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Cappello Silvia S Monzo Pascale P Vallee Richard B RB
Developmental biology 20110713 2
NudC is a highly conserved protein necessary for cytoplasmic dynein-mediated nuclear migration in Aspergillus nidulans. NudC interacts genetically with Aspergillus NudF and physically with its mammalian orthologue Lis1, which is crucial for nuclear and neuronal migration during brain development. To test for related roles for NudC, we performed in utero electroporation into embryonic rat brain of cDNAs encoding shRNAs as well as wild-type and mutant forms of NudC. We show here that NudC, like Li ...[more]