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Identification of variant-specific surface proteins in Giardia muris trophozoites.


ABSTRACT: Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to that of G. lamblia.

SUBMITTER: Ropolo AS 

PROVIDER: S-EPMC1201240 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature

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Identification of variant-specific surface proteins in Giardia muris trophozoites.

Ropolo Andrea S AS   Saura Alicia A   Carranza Pedro G PG   Lujan Hugo D HD  

Infection and immunity 20050801 8


Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to that of G. lamblia. ...[more]

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