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Variant-specific surface protein switching in Giardia lamblia.


ABSTRACT: Surface antigen switching in Giardia lamblia was analyzed using monoclonal antibodies specific for two variant-specific surface proteins (VSPs). Two VSPs were detected on the surface of single trophozoites. Dual expression persisted for 13 h but disappeared at 36 h, as in other parasites that undergo surface antigenic variation.

SUBMITTER: Nash TE 

PROVIDER: S-EPMC98104 | biostudies-literature | 2001 Mar

REPOSITORIES: biostudies-literature

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Variant-specific surface protein switching in Giardia lamblia.

Nash T E TE   Luján H T HT   Mowatt M R MR   Conrad J T JT  

Infection and immunity 20010301 3


Surface antigen switching in Giardia lamblia was analyzed using monoclonal antibodies specific for two variant-specific surface proteins (VSPs). Two VSPs were detected on the surface of single trophozoites. Dual expression persisted for 13 h but disappeared at 36 h, as in other parasites that undergo surface antigenic variation. ...[more]

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