Ontology highlight
ABSTRACT:
SUBMITTER: Benecke H
PROVIDER: S-EPMC1201347 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Benecke Heike H Lührmann Reinhard R Will Cindy L CL
The EMBO journal 20050811 17
U11 and U12 interact cooperatively with the 5' splice site and branch site of pre-mRNA as a stable preformed di-snRNP complex, thereby bridging the 5' and 3' ends of the intron within the U12-dependent prespliceosome. To identify proteins contributing to di-snRNP formation and intron bridging, we investigated protein-protein and protein-RNA interactions between components of the U11/U12 snRNP. We demonstrate that the U11/U12-65K protein possesses dual binding activity, interacting directly with ...[more]