Ontology highlight
ABSTRACT:
SUBMITTER: Will CL
PROVIDER: S-EPMC125580 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
Will C L CL Schneider C C MacMillan A M AM Katopodis N F NF Neubauer G G Wilm M M Lührmann R R Query C C CC
The EMBO journal 20010801 16
Previous UV cross-linking studies demonstrated that, upon integration of the U2 snRNP into the spliceosome, a 14 kDa protein (p14) interacts directly with the branch adenosine, the nucleophile for the first transesterification step of splicing. We have identified the cDNA encoding this protein by microsequencing a 14 kDa protein isolated from U2-type spliceosomes. This protein contains an RNA recognition motif and is highly conserved across species. Antibodies raised against this cDNA-encoded pr ...[more]