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Emergence of an influenza B virus with antigenic change.


ABSTRACT: Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity.

SUBMITTER: Nakagawa N 

PROVIDER: S-EPMC120617 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature

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Emergence of an influenza B virus with antigenic change.

Nakagawa Naoko N   Nukuzuma Souichi S   Haratome Shigekazu S   Go Shosan S   Nakagawa Toshimasa T   Hayashi Kozaburo K  

Journal of clinical microbiology 20020801 8


Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity. ...[more]

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