Ontology highlight
ABSTRACT:
SUBMITTER: Kondo M
PROVIDER: S-EPMC124237 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Kondo Mitsuhiro M Shibata Takahiro T Kumagai Takeshi T Osawa Toshihiko T Shibata Noriyuki N Kobayashi Makio M Sasaki Shoichi S Iwata Makoto M Noguchi Noriko N Uchida Koji K
Proceedings of the National Academy of Sciences of the United States of America 20020501 11
Prostaglandin D(2) (PGD(2)), a major cyclooxygenase product in a variety of tissues and cells, readily undergoes dehydration to yield the bioactive cyclopentenone-type PGs of the J(2)-series, such as 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)). The observation that the level of 15d-PGJ(2) increased in the tissue cells from patients with sporadic amyotrophic lateral sclerosis suggested that the formation of 15d-PGJ(2) may be closely associated with neuronal cell death during chronic inflammatory pr ...[more]