Ontology highlight
ABSTRACT:
SUBMITTER: Barton GM
PROVIDER: S-EPMC124507 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Barton Gregory M GM Beers Courtney C deRoos Paul P Eastman Susan R SR Gomez Marcela E ME Forbush Katherine A KA Rudensky Alexander Y AY
Proceedings of the National Academy of Sciences of the United States of America 20020501 10
If T cells require specific interactions with MHC-bound peptides during positive selection, then the specificities of T cells selected by one peptide should be distinct from those selected by another. We have examined positive selection of CD4 T cells in four strains of mice, each overexpressing a different peptide-1-A(b)(A(b)) complex. We show that a subset of CD4 T cells is selected by the overexpressed peptide and that the specificities of the CD4 T cells, as measured by reactivity to wild-ty ...[more]