Ontology highlight
ABSTRACT:
SUBMITTER: Cohen N
PROVIDER: S-EPMC125576 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
Cohen N N Sharma M M Kentsis A A Perez J M JM Strudwick S S Borden K L KL
The EMBO journal 20010801 16
The promyelocytic leukemia protein PML is organized into nuclear bodies which mediate suppression of oncogenic transformation and of growth. The biochemical functions of PML bodies are unknown, despite their involvement in several human disorders. We demonstrate that eukaryotic initiation factor 4E (eIF4E) directly binds the PML RING, a domain required for association with bodies and for suppression of transformation. Nuclear eIF4E functions in nucleocytoplasmic transport of a subset of transcri ...[more]