Ontology highlight
ABSTRACT:
SUBMITTER: Liss B
PROVIDER: S-EPMC125678 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Liss B B Franz O O Sewing S S Bruns R R Neuhoff H H Roeper J J
The EMBO journal 20011001 20
The activity of dopaminergic (DA) substantia nigra (SN) neurons is essential for voluntary movement control. An intrinsic pacemaker in DA SN neurons generates their tonic spontaneous activity, which triggers dopamine release. We show here, by combining multiplex and quantitative real-time single-cell RT- PCR with slice patch-clamp electrophysiology, that an A-type potassium channel mediated by Kv4.3 and KChip3 subunits has a key role in pacemaker control. The number of active A-type potassium ch ...[more]