Ontology highlight
ABSTRACT:
SUBMITTER: Donze O
PROVIDER: S-EPMC1271809 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Donzé Olivier O Deng Jing J Curran Joseph J Sladek Robert R Picard Didier D Sonenberg Nahum N
The EMBO journal 20040129 3
Cell death and survival play a key role in the immune system as well as during development. The control mechanisms that balance cell survival against cell death are not well understood. Here we report a novel strategy used by a single protein to regulate chronologically cell survival and death. The interferon-induced protein kinase PKR acts as a molecular clock by using catalysis-dependent and -independent activities to temporally induce cell survival prior to cell death. We show that the proapo ...[more]