Ontology highlight
ABSTRACT:
SUBMITTER: Soba P
PROVIDER: S-EPMC1276707 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
The EMBO journal 20050929 20
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease, but its physiological function and that of its mammalian paralogs, the amyloid precursor-like proteins 1 and 2 (APLPs), is still poorly understood. APP has been proposed to form dimers, a process that could promote cell adhesion via trans-dimerization. We investigated the dimerization and cell adhesion properties of APP/APLPs and provide evidence that all three paralogs are capable of forming homo- and heterocomplex ...[more]