AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump.
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ABSTRACT:
SUBMITTER: Wolter DJ
PROVIDER: S-EPMC1280130 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
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AmpC and OprD are not involved in the mechanism of imipenem hypersusceptibility among Pseudomonas aeruginosa isolates overexpressing the mexCD-oprJ efflux pump.
Wolter Daniel J DJ Hanson Nancy D ND Lister Philip D PD
Antimicrobial agents and chemotherapy 20051101 11
Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD. ...[more]
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