Ontology highlight
ABSTRACT:
SUBMITTER: Kocken CH
PROVIDER: S-EPMC128198 | biostudies-literature | 2002 Aug
REPOSITORIES: biostudies-literature
Kocken Clemens H M CH Withers-Martinez Chrislaine C Dubbeld Martin A MA van der Wel Annemarie A Hackett Fiona F Valderrama Augusto A Blackman Michael J MJ Thomas Alan W AW
Infection and immunity 20020801 8
Apical membrane antigen 1 (AMA-1) is a highly promising malaria blood-stage vaccine candidate that has induced protection in rodent and nonhuman primate models of malaria. Authentic conformation of the protein appears to be essential for the induction of parasite-inhibitory antibody responses. Here we have developed a synthetic gene with adapted codon usage to allow expression of Plasmodium falciparum FVO strain AMA-1 (PfAMA-1) in Pichia pastoris. In addition, potential N-glycosylation sites wer ...[more]