Ontology highlight
ABSTRACT:
SUBMITTER: Sun YH
PROVIDER: S-EPMC128286 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Sun Yao-Hui YH den Hartigh Andreas B AB Santos Renato Lima RL Adams L Garry LG Tsolis Renée M RM
Infection and immunity 20020901 9
The Brucella abortus virB locus is required for establishing chronic infection in the mouse. Using in vitro and in vivo models, we investigated whether virB is involved in evasion of the bactericidal activity of NADPH oxidase and the inducible nitric oxide synthase (iNOS) in macrophages. Elimination of NADPH oxidase or iNOS activity in macrophages in vitro increased recovery of wild-type B. abortus but not recovery of a virB mutant. In mice lacking either NADPH oxidase or iNOS, however, B. abort ...[more]