Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC1291244 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Li Lin L Carter John J Gao Xiaoguang X Whitehead Jennifer J Tourtellotte Warren G WG
Molecular and cellular biology 20051201 23
Early growth response (Egr) transcription factors (Egr1 to Egr4) are synaptic activity-inducible immediate early genes (IEGs) that regulate some aspects of synaptic plasticity-related to learning and memory, yet the target genes regulated by them are unknown. In particular, Egr1 is essential for persistence of late-phase long-term potentiation (L-LTP), for hippocampus-dependent long-term memory formation, and for reconsolidation of previously established memories. Here, we show that Egr1 and Egr ...[more]