Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC7781917 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kim JuHwan J Jung Euitaek E Ahn Sung Shin SS Yeo Hyunjin H Lee Jeong Yeon JY Seo Jeong Kon JK Lee Young Han YH Shin Soon Young SY
BMB reports 20201201 12
WNT11 is a member of the non-canonical Wnt family and plays a crucial role in tumor progression. However, the regulatory mechanisms underlying WNT11 expression are unclear. Tumor necrosis factor-alpha (TNFα) is a major inflammatory cytokine produced in the tumor microenvironment and contributes to processes associated with tumor progression, such as tumor invasion and metastasis. By using site-directed mutagenesis and introducing a serial deletion in the 5'-regulatory region of WNT11, we observe ...[more]