Ontology highlight
ABSTRACT:
SUBMITTER: Chiang IK
PROVIDER: S-EPMC5536923 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Chiang Ivy Kim-Ni IK Fritzsche Martin M Pichol-Thievend Cathy C Neal Alice A Holmes Kelly K Lagendijk Anne A Overman Jeroen J D'Angelo Donatella D Omini Alice A Hermkens Dorien D Lesieur Emmanuelle E Liu Ke K Ratnayaka Indrika I Corada Monica M Bou-Gharios George G Carroll Jason J Dejana Elisabetta E Schulte-Merker Stefan S Hogan Benjamin B Beltrame Monica M De Val Sarah S Francois Mathias M
Development (Cambridge, England) 20170615 14
Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification has not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human <i>NOTCH1</i> and zebraf ...[more]