Ontology highlight
ABSTRACT:
SUBMITTER: Kelly JA
PROVIDER: S-EPMC129343 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Kelly Jennifer A JA Thompson Kevin K Kilpatrick Jeff J Lam Tom T Nath Swapan K SK Gray-McGuire Courtney C Reid Jeff J Namjou Bahram B Aston Christopher E CE Bruner Gail R GR Scofield R Hal RH Harley John B JB
Proceedings of the National Academy of Sciences of the United States of America 20020821 18
Hemolytic anemia is a forme fruste of systemic lupus erythematosus (SLE), being observed months or even years before the onset of other clinical manifestations in some patients. We hypothesized that hemolytic anemia in those SLE-affected patients would identify a group of SLE pedigrees that share a high degree of genetic homogeneity. From 160 multiplex SLE pedigrees, we sought evidence for linkage in 35 (16 African-American, 17 European-American, and 2 Hispanic) who had at least one SLE-affected ...[more]