Ontology highlight
ABSTRACT:
SUBMITTER: Castellano S
PROVIDER: S-EPMC1298953 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Castellano Sergi S Novoselov Sergey V SV Kryukov Gregory V GV Lescure Alain A Blanco Enrique E Krol Alain A Gladyshev Vadim N VN Guigó Roderic R
EMBO reports 20040101 1
While the genome sequence and gene content are available for an increasing number of organisms, eukaryotic selenoproteins remain poorly characterized. The dual role of the UGA codon confounds the identification of novel selenoprotein genes. Here, we describe a comparative genomics approach that relies on the genome-wide prediction of genes with in-frame TGA codons, and the subsequent comparison of predictions from different genomes, wherein conservation in regions flanking the TGA codon suggests ...[more]