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Crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.

ABSTRACT: The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins.

SUBMITTER: Vilmos P

PROVIDER: S-EPMC1299258 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature

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crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.

Vilmos Peter P Sousa-Neves Rui R Lukacsovich Tamas T Marsh J Lawrence JL

EMBO reports 20050301 3

The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These finding ...[more]

PMID: 15711536

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