A computational model of mitochondrial AZT metabolism.
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ABSTRACT:
SUBMITTER: Bradshaw PC
PROVIDER: S-EPMC1316272 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Publications
A computational model of mitochondrial AZT metabolism.
Bradshaw Patrick C PC Li Jiaxin J Samuels David C DC
The Biochemical journal 20051201 Pt 2
The mechanisms of the mitochondrial toxicity of AZT (azidothymidine; zidovudine) are not clear. The two main contenders are the incorporation of phosphorylated AZT into the mtDNA (mitochondrial DNA) and the competitive inhibition of natural deoxynucleotide metabolism. We have built a computational model of AZT metabolism in mitochondria in order to better understand these toxicity mechanisms. The model includes the transport of non-phosphorylated and phosphorylated forms of AZT into mitochondria ...[more]
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