Ontology highlight
ABSTRACT:
SUBMITTER: Link N
PROVIDER: S-EPMC1356536 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Link Nils N Aubel Corinne C Kelm Jens M JM Marty René R RR Greber David D Djonov Valentin V Bourhis Jean J Weber Wilfried W Fussenegger Martin M
Nucleic acids research 20060130 2
The straightforward production and dose-controlled administration of protein therapeutics remain major challenges for the biopharmaceutical manufacturing and gene therapy communities. Transgenes linked to HIV-1-derived vpr and pol-based protease cleavage (PC) sequences were co-produced as chimeric fusion proteins in a lentivirus production setting, encapsidated and processed to fusion peptide-free native protein in pseudotyped lentivirions for intracellular delivery and therapeutic action in tar ...[more]