Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC4415702 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chen Zhonglei Z Grzybowski Adrian T AT Ruthenburg Alexander J AJ
Chembiochem : a European journal of chemical biology 20140822 14
Considerable mechanistic insight into the function of histone post-translational modifications and the enzymes that install and remove them derives from in vitro experiments with modified histones, often embedded in nucleosomes. We report the first semisyntheses of native-like histone 3 (H3) bearing tri- and dimethyllysines at position 79 and trimethyllysine at position 36, as well as more facile and traceless semisyntheses of K9 and K27 trimethylated species. These semisyntheses are practical o ...[more]