Ontology highlight
ABSTRACT:
SUBMITTER: Qureshi A
PROVIDER: S-EPMC1408682 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Qureshi Amer A Zheng Richard R Parlett Terry T Shi Xiaoju X Balaraman Priyadhashini P Cheloufi Sihem S Murphy Brendan B Guntermann Christine C Eagles Peter P
The Biochemical journal 20060301 Pt 2
The chemokine receptors CXCR4 and CCR5 are required for HIV-1 to enter cells, and the progression of HIV-1 infection to AIDS involves a switch in the co-receptor usage of the virus from CCR5 to CXCR4. These receptors therefore make attractive candidates for therapeutic intervention, and we have investigated the silencing of their genes by using ribozymes and single-stranded antisense RNAs. In the present study, we demonstrate using ribozymes that a depletion of CXCR4 and CCR5 mRNAs can be achiev ...[more]