Ontology highlight
ABSTRACT:
SUBMITTER: Sieber JJ
PROVIDER: S-EPMC1414554 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Sieber Jochen J JJ Willig Katrin I KI Heintzmann Rainer R Hell Stefan W SW Lang Thorsten T
Biophysical journal 20060127 8
In the plasma membrane, syntaxin 1 and syntaxin 4 clusters define sites at which secretory granules and caveolae fuse, respectively. It is widely believed that lipid phases are mandatory for cluster formation, as cluster integrity depends on cholesterol. Here we report that the native lipid environment is not sufficient for correct syntaxin 1 clustering and that additional cytoplasmic protein-protein interactions, primarily involving the SNARE motif, are required. Apparently no specific cofactor ...[more]